RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Smad2
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
Dual-luciferase reporter assay; PCR etc.
Target
Smad2; Tgfa
Pathway
NA
PubMed ID
Title
MiR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways
Year
2016
Function
"MiR-323a-3p is downregulated in the epithelium of lungs with bronchiolitis obliterans syndrome (BOS) after lung transplantation, idiopathic pulmonary fibrosis (IPF), and murine bleomycin-induced fibrosis. MiR-323a-3p attenuates TGF-a and TGF-B signaling by directly targeting SMAD2 and TGFA. Moreover, miR-323a-3p lowers caspase-3 expression, thereby limiting programmed cell death from inducers of apoptosis and ER stress. Epithelial expression of miR-323a-3p modulates inhibitory crosstalk with fibroblasts. Downregulated expression of miR-323a-3p by the lung epithelium releases inhibition of various profibrotic pathways to promote fibroproliferation."